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AntarDhwani

HLA-B27: What’s New?

The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the aetiopathogenesis of SpA and other diseases, and its protective action in certain infections, continue to challenge our understanding of its immunobiology and ph
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Genetics

There is a strong familial tendency with >90% of the risk of disease determined genetically. A strong association with HLA-B27 exists, particularly in white western European populations. Approximately 1-2% of all people who are positive for HLA-B2
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Basics of Ankylosing Spondylitis

Almost all people with ankylosing spondylitis can expect to lead normal and productive lives. Despite the chronic nature of the illness, only a few people with ankylosing spondylitis will become severely disabled. The management of pain and the contr
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Ramifications of HLA-B27

Thirty years after its discovery, the association between HLA-B27 and ankylosing spondylitis remains the strongest known relationship between a major histocompatibility complex (MHC) antigen and a disease. Epidemiological studies in the 1960s and ear
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