COVID-19/Coronavirus - Advice and guidance for people living with Ankylosing Spondylitis. Learn more here.

Education and preventive care

Evidence and rationale. Self-management education interventions in AS were tested in 5 controlled trials, with generally small but significant improvements in measures of disease activity and health status.
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Arthritis and Ankylosing Spondylitis

Ankylosing spondylitis is a type of arthritis that affects the spine. Ankylosing spondylitis symptoms include pain and stiffness from the neck down to the lower back. The spine's bones (vertebrae) may grow or fuse together, resulting in a rigid spine. T
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HLA-B27: What’s New?

The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the aetiopathogenesis of SpA and other diseases, and its protective action in certain infections, continue to challenge our understanding of its immunobiology and physi
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Genetics

There is a strong familial tendency with >90% of the risk of disease determined genetically. A strong association with HLA-B27 exists, particularly in white western European populations. Approximately 1-2% of all people who are positive for HLA-B27
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Basics of Ankylosing Spondylitis

Almost all people with ankylosing spondylitis can expect to lead normal and productive lives. Despite the chronic nature of the illness, only a few people with ankylosing spondylitis will become severely disabled. The management of pain and the control
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Ramifications of HLA-B27

Thirty years after its discovery, the association between HLA-B27 and ankylosing spondylitis remains the strongest known relationship between a major histocompatibility complex (MHC) antigen and a disease. Epidemiolo
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Symptoms and Signs

The most frequent manifestation is back pain, but disease can begin in peripheral joints, especially in children and women, and rarely with acute iridocyclitis (iritis or anterior uveitis). Other early symptoms and signs are diminished chest expansion f
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Leaky Gut Syndromes: Breaking The Vicious Cycle

From the perspective of function, the contents of the gut lumen lie outside the body and contain a toxic/antigenic load from which the body needs to be protected. Protection is supplied by complex mechanisms which support one another: intestinal secreti
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Diagnosis of AS

History: Individuals typically complain of a gradual onset of low back pain and associated muscle spasms experienced over several months. The pain is usually described as worse in the morning and improving during the day. It may have followed a gradual
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