Symptoms and Signs

The most frequent manifestation is back pain, but disease can begin in peripheral joints, especially in children and women, and rarely with acute iridocyclitis (iritis or anterior uveitis). Other early symptoms and signs are diminished chest expansio
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Leaky Gut Syndromes: Breaking The Vicious Cycle

From the perspective of function, the contents of the gut lumen lie outside the body and contain a toxic/antigenic load from which the body needs to be protected. Protection is supplied by complex mechanisms which support one another: intestinal secr
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Diagnosis of AS

History: Individuals typically complain of a gradual onset of low back pain and associated muscle spasms experienced over several months. The pain is usually described as worse in the morning and improving during the day. It may have followed a gradu
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Is Ankylosing Spondylitis Hereditary?

Although ankylosing spondylitis causes are unknown, there appears to be a genetic prevalence to the disease (transmitted from parents to children) for most people. Many children with this disease were born displaying a given HLA-B27 gene. However, if
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